Advancing precision medicine with computational modelling
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Who We Are

The Molecular Systems Physiology group, headed by Prof. Ines Thiele, aims to improve our understanding of how diet influences human health.

 

We use a computational modeling approach, termed constraint-based modeling, which has gained increasing importance in systems biology. In this approach, comprehensive computational models are assembled in a bottom-up manner from literature and genomic information. These models describe in a stoichiometric accurate format biochemical transformations occurring in a target organism. Once assembled, various omics data sets can be integrated and analyzed with these models, expanding currently available analysis tools and thus providing mechanistically based insight into complex multi-dimensional data sets. Moreover, these models can be used to predict the impact of genetic alterations (e.g., enzyme deficiencies) and of changed environment conditions (e.g., changes in diet composition) on the metabolic state of the target organism. The molecular systems physiology group builds comprehensive models of human cells and human-associated microbes. We then employ these models together with experimental data to investigate how nutrition and genetic predisposition can affect one’s health. In particular, we are interested in applying our computational modeling approach for better understanding of inherited and neurodegenerative diseases. 

Research Projects

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Virtual

Metabolic Human

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BugTheDrug

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Method & Tool

Development

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Parkinson's

Disease

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Gut-Brain-Axis​ In Alzheimer's Disease

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Host-microbe

Co-metabolism

 

Publications

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Database

The VMH

A multitude of factors contribute to complex diseases and can be measured with ‘omics’ methods. Databases facilitate data inter-pretation for underlying mechanisms ...

 

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Tools

The COBRA Toolbox

Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental molecular systems biology  ...

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Reconstructions

Whole-body organ-resolved models of human metabolism

We have assembled  and analysed the first sex-specific, anatomically accurate, organ-specific metabolic reconstruction 

 

In silico Models

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Microbial metabolic reconstructions

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Whole-body organ-resolved metabolic reconstructions

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Host-microbiome co-metabolism models

 

CONTACT US

NATIONAL UNIVERSITY OF IRELAND, GALWAY

School of Medicine

School of Natural Sciences

Discipline of Microbiology

Orbsen Building

Room 312

University Road

Galway, Ireland

H91 TK33

 

ines.thiele_at_nuigalway.ie


Tel: (+353) 91 49 5201 

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